1792. Different Patterns of Antibiotic Use in Different Administrative Categories: An Overview of 10 years (2009/2018) of a Statewide Surveillance Program in Sao Paulo, Brazil

Abstract Background To describe intensive care unit (ICU) antibiotic use in different administrative categories based on data reported to the Nosocomial Surveillance System of State Health Department (SHD) Sao Paulo. Methods This ecological study describes at an aggregated level adult ICU São Paulo SHD, from 2009 2018. ICUs were categorized by hospital category (private, public, and philanthropic). Public hospitals subdivided into two sub-categories as Social Organization (SHO), which administration is private but public funded, or direct (DPA). Resistance phenotype incidence correlation was calculated for meticilin-resistant Staphylococcus aureus (MRSA) glycopeptide use, third generation cephalosporin (3GC)-resistant Enterobacterales carbapenem carbapenem-resistant gram-negative bacilli (CR-GNB) polymyxins use. Results The average number reporting annual 386. A total 17.490.966 patient-days included. Total increased 588.16 943.12 DDD/1000pd 2018 (p< 0,01). DDD (defined daily dose) higher (mean 889.11 DDD/1000pd), than 849.07 DDD/1000pd) philanthropic 48 785.12 0.05). Positive correlations detected between MRSA incidence, CR-GNB incidence. weak negative carbapenems 3GC-resistante found. Figure I:Antimicrobial therapeutic class / 1000 patient-daysTable I:Antibiotic type DDD/1000 patients-dayTable II:Antibiotic subgroup patients-day Conclusion We found antibiotics philanthropic. Differences observed among SHO e DPA hospitals. These provide important information formulating hypotheses health strategies improve antimicrobial prescription. Disclosures All Authors: No disclosures.